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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook_2014     Display Documents



ID: 682135.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook_2014
Pulmonary hypertension due to left heart diseases
Authors:Vachiery, J. L.; Adir, Y.; Barbera, J. A.; Champion, H.; Coghlan, J. G.; Cottin, V.; De Marco, T.; Galie, N.; Ghio, S.; Gibbs, J. S.; Martinez, F.; Semigran, M.; Simonneau, G.; Wells, A.; Seeger, W.
Date of Publication (YYYY-MM-DD):2013-12-24
Journal Abbrev.:J Am Coll Cardiol
Volume:62
Issue / Number:25 Suppl
Start Page:D100
End Page:8
Audience:Not Specified
Abstract / Description:Pulmonary hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms, exercise capacity, and outcome. Although the true prevalence of PH-LHD is unknown, a subset of patients might present significant PH that cannot be explained by a passive increase in left-sided filling pressures. The term "out-of-proportion" PH has been used to identify that population without a clear definition, which has been found less than ideal and created confusion. We propose a change in terminology and a new definition of PH due to LHD. We suggest to abandon "out-of-proportion" PH and to distinguish "isolated post-capillary PH" from "post-capillary PH with a pre-capillary component" on the basis of the pressure difference between diastolic pulmonary artery pressure and pulmonary artery wedge pressure. Although there is no validated treatment for PH-LHD, we provide insights into management and discuss completed and randomized trials in this condition. Finally, we provide recommendations for future clinical trials to establish safety and efficacy of novel compounds to target this area of unmet medical need.
Free Keywords:Animals; Clinical Trials as Topic/methods; Humans; Hypertension, Pulmonary/*diagnosis/*epidemiology/therapy; Pulmonary Wedge Pressure/physiology; Vascular Resistance/physiology; Ventricular Dysfunction, Left/*diagnosis/*epidemiology/therapy
External Publication Status:published
Document Type:Article
Communicated by:Svea Hümmer
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Pulmonary Division, Lady Davis Carmel Medical Center, Faculty of Medicine, The Technion, Institute of Technology, Haifa, Israel. Hospital Clinic-IDIBAPS, University of Barcelona, Network Center of Biomedical Research on Respiratory Diseases (CIBERES), Barcelona, Spain. University of Pittsburgh Medical Center Montefiore Hospital, Pittsburgh, Pennsylvania. Department of Cardiology Royal Free Hospital, London, United Kingdom. Hospices Civils de Lyon, Louis Pradel Hospital, Department of Respiratory Diseases, National Reference Center for Rare Pulmonary Diseases, Regional Competence Center for Severe Pulmonary Arterial Hypertension; Claude Bernard University Lyon 1, Lyon, France. University of California, San Francisco, San Francisco, California. Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Bologna University Hospital, Bologna, Italy. Divisione di Cardiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. National Heart and Lung Institute, Imperial College London and Department of Cardiology, National Pulmonary Hypertension Service, Hammersmith Hospital, London, United Kingdom. Division of Pulmonary and Critical Care, University of Michigan Medical Center, Ann Arbor, Michigan. MGH Heart Failure and Cardiac Transplantation Center, Massachusetts General Hospital, Boston, Massachusetts. Service de Pneumologie, Hopital Universitaire de Bicetre, APHP, Universite Paris-Sud, Laboratoire d'excellence en recherche sur le medicament et innovation therapeutique, and INSERM, Le Kremlin Bicetre, France. Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom. University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Max-Planck Institute for Heart and Lung Research, Giessen/Bad Nauheim, Germany.
Identifiers:ISSN:1558-3597 (Electronic) 0735-1097 (Linking) %R 10.1016/j.jacc.2013.10.033
URL:http://www.ncbi.nlm.nih.gov/pubmed/24355634
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