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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook_2014     Display Documents



ID: 682214.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook_2014
Regulation of angiogenesis by PI3K signaling networks
Authors:Graupera, M.; Potente, M.
Date of Publication (YYYY-MM-DD):2013-05-15
Journal Abbrev.:Exp Cell Res
Volume:319
Issue / Number:9
Start Page:1348
End Page:1355
Audience:Not Specified
Abstract / Description:Phosphoinositide 3-kinases (PI3Ks) are an evolutionary conserved family of lipid kinases that control cell growth, metabolism and survival. By generating lipid second messengers that interact with specialized lipid-binding domains found in a wide spectrum of signaling molecules, PI3Ks instigate signaling through a network of downstream effector pathways. Genetic studies in zebrafish and mice revealed the critical importance of intact PI3K signaling in the endothelium and provided first insights into how individual PI3K isoforms are utilized to control vascular development and function. Here, we review the myriad roles of PI3Ks in the endothelium and the mechanisms through which they couple environmental signals with specific steps of angiogenic vessel growth.
Free Keywords:Animals; Humans; Isoenzymes/physiology; Neoplasms/blood supply; Neovascularization, Pathologic/*enzymology; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases/*physiology; Phosphorylation; *Protein Processing, Post-Translational; Receptors, Vascular Endothelial Growth Factor/metabolism; *Signal Transduction; Vascular Endothelial Growth Factor A/physiology
External Publication Status:published
Document Type:Article
Communicated by:Svea Hümmer
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:%W NLM %G eng
Identifiers:ISSN:0014-4827 %R 10.1016/j.yexcr.2013.02.021
URL:http://ac.els-cdn.com/S0014482713000979/1-s2.0-S00...
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