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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook_2014     Display Documents



ID: 682224.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook_2014
Sleep apnea in precapillary pulmonary hypertension
Authors:Dumitrascu, R.; Tiede, H.; Eckermann, J.; Mayer, K.; Reichenberger, F.; Ghofrani, H. A.; Seeger, W.; Heitmann, J.; Schulz, R.
Date of Publication (YYYY-MM-DD):2013-03
Journal Abbrev.:Sleep Med
Volume:14
Issue / Number:3
Start Page:247
End Page:251
Audience:Not Specified
Abstract / Description:OBJECTIVES: Pilot studies have described the occurrence of sleep apnea in patients with precapillary pulmonary hypertension (PH). However, there are no data on the prevalence of sleep-related breathing disorders in larger patient cohorts with PH. METHODS: 169 patients with a diagnosis of PH confirmed by right heart catheterisation and clinically stable in NYHA classes II or III were prospectively investigated by polygraphy (n = 105 females, mean age: 61.3 years, mean body mass index: 27.2 kg/m(2)). Recruitment was independent of sleep-related symptoms and the use of vasodilator drugs or nasal oxygen. RESULTS: 45 patients (i.e. 26.6%) had an apnea-hypopnea-index (AHI) >10/h. Of these, 27 patients (i.e. 16%) had obstructive sleep apnea (OSA) and 18 patients (i.e. 10.6%) had central sleep apnea (CSA). The mean AHI was 20/hour. As a polygraphy had been performed with nasal oxygen in half of the patients without evidence for sleep apnea, the frequency of CSA was probably underestimated. Patients with OSA were characterized by male gender and higher body mass index whereas, those with CSA were older and hypocapnic. CONCLUSIONS: At least every fourth patient with PH suffers from mild-to-moderate sleep apnea. Considering the anthropometric characteristics of the patients studied, the prevalence of both OSA and CSA seem to be higher in PH than in the general population.
Free Keywords:Adult; Aged; Body Mass Index; Capillaries; Cardiac Catheterization; Disorders of Excessive Somnolence/diagnosis/epidemiology; Female; Humans; Hypertension, Pulmonary/diagnosis/*epidemiology; Hypocapnia/diagnosis/*epidemiology; Male; Middle Aged; Polysomnography; Prevalence; Prospective Studies; *Pulmonary Circulation; Risk Factors; Severity of Illness Index; Sleep Apnea, Obstructive/diagnosis/*epidemiology
External Publication Status:published
Document Type:Article
Communicated by:Svea Hümmer
Affiliations:MPI für physiologische und klinische Forschung
Identifiers:ISSN:1878-5506 (Electronic) 1389-9457 (Linking) %R 10.1016/j.sleep.2012.11.013
URL:http://www.ncbi.nlm.nih.gov/pubmed/23340085
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