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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook_2014     Display Documents



ID: 682225.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook_2014
Obstructive sleep apnea, oxidative stress and cardiovascular disease: lessons from animal studies
Authors:Dumitrascu, R.; Heitmann, J.; Seeger, W.; Weissmann, N.; Schulz, R.
Date of Publication (YYYY-MM-DD):2013
Journal Abbrev.:Oxid Med Cell Longev
Volume:2013
Start Page:234631
Audience:Not Specified
Abstract / Description:Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular (CV) diseases such as arterial hypertension, heart failure, and stroke. Based on human research, sympathetic activation, inflammation, and oxidative stress are thought to play major roles in the pathophysiology of OSA-related CV diseases. Animal models of OSA have shown that endothelial dysfunction, vascular remodelling, and systemic and pulmonary arterial hypertension as well as heart failure can develop in response to chronic intermittent hypoxia (CIH). The available animal data are clearly in favour of oxidative stress playing a key role in the development of all of these CV manifestations of OSA. Presumably, the oxidative stress is due to an activation of NADPH oxidase and other free oxygen radicals producing enzymes within the CV system as evidenced by data from knockout mice and pharmacological interventions. It is hoped that animal models of OSA-related CV disease will continue to contribute to a deeper understanding of their underlying pathophysiology and will foster the way for the development of cardioprotective treatment options other than conventional CPAP therapy.
Free Keywords:Animals; Cardiovascular Diseases/etiology/metabolism/*physiopathology; Endothelium, Vascular/physiopathology; Heart Failure/etiology/physiopathology; Humans; Hypertension/etiology/physiopathology; NADPH Oxidase/metabolism; Oxidative Stress; Reactive Oxygen Species/metabolism; Sleep Apnea, Obstructive/complications/metabolism/*physiopathology
External Publication Status:published
Document Type:Article
Communicated by:Svea Hümmer
Affiliations:MPI für physiologische und klinische Forschung
Identifiers:ISSN:1942-0994 (Electronic) %R 10.1155/2013/234631
URL:http://www.ncbi.nlm.nih.gov/pubmed/23533685
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