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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2013 (arch)     Display Documents



ID: 688451.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2013 (arch)
Dynein Motion Switches from Diffusive to Directed upon Cortical Anchoring
Authors:Ananthanarayanan, Vaishnavi; Schattat, Martin; Vogel, Sven; Krull, Alexander; Pavin, Nenad; Tolic-Norrelykke, Iva M.
Date of Publication (YYYY-MM-DD):2013
Title of Journal:Cell
Volume:153
Issue / Number:7
Start Page:1526
End Page:1536
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Cytoplasmic dynein is a motor protein that exerts force on microtubules. To generate force for the movement of large organelles, dynein needs to be anchored, with the anchoring sites being typically located at the cell cortex. However, the mechanism by which dyneins target sites where they can generate large collective forces is unknown. Here, we directly observe single dyneins during meiotic nuclear oscillations in fission yeast and identify the steps of the dynein binding process: from the cytoplasm to the microtubule and from the microtubule to cortical anchors. We observed that dyneins on the microtubule move either in a diffusive or directed manner, with the switch from diffusion to directed movement occurring upon binding of dynein to cortical anchors. This dual behavior of dynein on the microtubule, together with the two steps of binding, enables dyneins to self-organize into a spatial pattern needed for them to generate large collective forces.
External Publication Status:published
Document Type:Article
Communicated by:Lib
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:5333
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