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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2013 (arch)     Display Documents



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ID: 688490.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2013 (arch)
Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells.
Authors:Zietara, Natalia; Lyszkiewicz, Marcin; Witzlau, Katrin; Naumann, Ronald; Hurwitz, Robert; Langemeier, Jörg; Bohne, Jens; Sandrock, Inga; Ballmaier, Matthias; Weiss, Siegfried; Prinz, Immo; Krueger, Andreas
Date of Publication (YYYY-MM-DD):2013
Title of Journal:Proceedings of the National Academy of Sciences of the United States of America
Volume:110
Issue / Number:18
Start Page:7407
End Page:7412
Copyright:not available
Review Status:Internal review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:T-cell receptor (TCR) signal strength determines selection and lineage fate at the CD4(+)CD8(+) double-positive stage of intrathymic T-cell development. Members of the miR-181 family constitute the most abundantly expressed microRNA at this stage of T-cell development. Here we show that deletion of miR-181a/b-1 reduced the responsiveness of double-positive thymocytes to TCR signals and virtually abrogated early invariant natural killer T (iNKT) cell development, resulting in a dramatic reduction in iNKT cell numbers in thymus as well as in the periphery. Increased concentrations of agonist ligand rescued iNKT cell development in miR-181a/b-1(-/-) mice. Our results define a critical role of miR-181a/b-1 in early iNKT cell development and show that miR-181a/b-1 sets a TCR signaling threshold for agonist selection.
External Publication Status:published
Document Type:Article
Communicated by:Lib
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:5641
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