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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2013 (arch)     Display Documents

ID: 688549.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2013 (arch)
Fission Yeast Does Not Age under Favorable Conditions, but Does So after Stress.
Authors:Coelho, Miguel; Dereli, Aygul; Haese, Anett; Kühn, Sebastian; Malinovska, Liliana; Desantis, Morgan E; Shorter, James; Alberti, Simon; Gross, Thilo; Tolic-Norrelykke, Iva M.
Date of Publication (YYYY-MM-DD):2013
Title of Journal:Current Biology : CB
Issue / Number:19
Start Page:1844
End Page:1852
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Background Many unicellular organisms age: as time passes they divide more slowly and ultimately die. In budding yeast, asymmetric segregation of cellular damage results in aging mother cells and rejuvenated daughters. We hypothesize that the organisms in which this asymmetry is lacking, or can be modulated, may not undergo aging. Results We performed a complete pedigree analysis of micro-colonies of the fission yeast Schizosaccharomyces pombe growing from a single cell. When cells were grown under favourable conditions, none of the lineages exhibited aging, which is defined as a consecutive increase in division time and increased death probability. Under favourable conditions, few cells died and their death was random and sudden rather than following a gradual increase in division time. Cell death correlated with the inheritance of Hsp104-associated protein aggregates. After stress, the cells that inherited large aggregates aged, showing a consecutive increase in division time and an increased death probability. Their sisters, who inherited little or no aggregates, did not age. Conclusions We conclude that S. pombe does not age under favourable growth conditions, but does so under stress. This transition appears to be passive rather than active and results from the formation of a single large aggregate, which segregates asymmetrically at the subsequent cell division. We argue that this damage-induced asymmetric segregation has evolved to sacrifice some cells so that others may survive unscathed after severe environmental stresses.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Lib
Affiliations:MPI für molekulare Zellbiologie und Genetik
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