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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2013 (arch)     Display Documents



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ID: 688600.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2013 (arch)
Dynein, microtubule and cargo: a ménage à trois.
Authors:Pavin, Nenad; Tolic-Norrelykke, Iva M.
Date of Publication (YYYY-MM-DD):2013
Title of Journal:Biochemical Society Transactions
Volume:41
Issue / Number:6
Start Page:1731
End Page:1735
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:To exert forces, motor proteins bind with one end to cytoskeletal filaments, such as microtubules and actin, and with the other end to the cell cortex, a vesicle or another motor. A general question is how motors search for sites in the cell where both motor ends can bind to their respective binding partners. In the present review, we focus on cytoplasmic dynein, which is required for a myriad of cellular functions in interphase, mitosis and meiosis, ranging from transport of organelles and functioning of the mitotic spindle to chromosome movements in meiotic prophase. We discuss how dynein targets sites where it can exert a pulling force on the microtubule to transport cargo inside the cell.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Lib
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:5546
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