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          Institute: Ernst Strüngmann Institute     Collection: Publikationen des Ernst Strüngmann Institutes     Display Documents

ID: 689111.0, Ernst Strüngmann Institute / Publikationen des Ernst Strüngmann Institutes
Motion-Sensitive Responses in Visual Area V4 in the Absence of Primary Visual Cortex
Authors:Schmid, M. C.; Schmiedt, J. T.; Peters, A. J.; Saunders, R. C.; Maier, A.; Leopold, D. A.
Date of Publication (YYYY-MM-DD):2013-11-27
Journal Abbrev.:Journal of Neuroscience
Issue / Number:48
Start Page:18740
End Page:18745
Audience:Not Specified
Abstract / Description:Neurons in cortical ventral-stream area V4 are thought to contribute to important aspects of visual processing by integrating information from primary visual cortex (V1). However, how V4 neurons respond to visual stimulation after V1 injury remains unclear: While electrophysiological investigation of V4 neurons during reversible V1 inactivation suggests that virtually all responses are eliminated (Girard et al., 1991), fMRI in humans and monkeys with permanent lesions shows reliable V1-independent activity (Baseler et al., 1999; Goebel et al., 2001; Schmid et al., 2010). To resolve this apparent discrepancy, we longitudinally assessed neuronal functions of macaque area V4 using chronically implanted electrode arrays before and after creating a permanent aspiration lesion in V1. During the month after lesioning, we observed weak yet significant spiking activity in response to stimuli presented to the lesion-affected part of the visual field. These V1-independent responses showed sensitivity for motion and likely reflect the effect of V1-bypassing geniculate input into extrastriate areas.
Free Keywords:lateral geniculate-nucleus; superior colliculus; striate cortex; macaque monkey; afferent basis; mt; organization; neurons; pathways; input
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:Ernst Strüngmann Institute
External Affiliations:Max Planck Gesell, Ernst Strungmann Inst Neurosci, Deutschordenstr 46, D-60528 Frankfurt, Germany Max Planck Gesell, Ernst Strungmann Inst Neurosci, D-60528 Frankfurt, Germany Univ Calif San Diego, La Jolla, CA 92093 USA Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA NIMH, Lab Neuropsychol, Bethesda, MD 20892 USA NIMH, Neurophysiol Imaging Facil, Natl Inst Neurol Disorders & Stroke, Bethesda, MD 20892 USA NEI, Bethesda, MD 20892 USA %G English
Identifiers:ISSN:0270-6474 %R http://dx.doi.org/10.1523/JNEUROSCI.3... [ID No:1]
URL:<Go to ISI>://WOS:000327741400005 [ID No:2]
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