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          Institute: Ernst Strüngmann Institute     Collection: Publikationen des Ernst Strüngmann Institutes     Display Documents



ID: 689138.0, Ernst Strüngmann Institute / Publikationen des Ernst Strüngmann Institutes
Repetition Suppression versus Enhancement-It's Quantity That Matters
Authors:Müller, N. G.; Strumpf, H.; Scholz, M.; Baier, B.; Melloni, L.
Date of Publication (YYYY-MM-DD):2013-02
Journal Abbrev.:Cerebral Cortex
Volume:23
Issue / Number:2
Start Page:315
End Page:322
Audience:Not Specified
Abstract / Description:Upon repetition, certain stimuli induce reduced neural responses (i.e., repetition suppression), whereas others evoke stronger signals (i.e., repetition enhancement). It has been hypothesized that stimulus properties (e.g., visibility) determine the direction of the repetition effect. Here, we show that the very same stimuli can induce both repetition suppression and enhancement, whereby the only determining factor is the number of repetitions. Repeating the same, initially novel low-visible pictures of scenes for up to 5 times enhanced the blood oxygen level-dependent (BOLD) response in scene-selective areas, that is, the parahippocampal place area (PPA) and the transverse occipital sulcus (TOS), presumably reflecting the strengthening of the internal representation. Additional repetitions (6-9) resulted in progressively attenuated neural responses indicating a more efficient representation of the now familiar stimulus. Behaviorally, repetition led to increasingly faster responses and higher visibility ratings. Novel scenes induced the largest BOLD response in the PPA and also higher activity in yet another scene-selective region, the retrospenial cortex (RSC). We propose that 2 separable processes modulate activity in the PPA: one process optimizes the internal stimulus representation and involves TOS and the other differentiates between familiar and novel scenes and involves RSC.
Free Keywords:fmri; novelty detection; priming; repetition suppression; event-related fmri; human parahippocampal cortex; neural mechanisms; spatial attention; recognition; brain; expectations; performance; activation; responses
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:Ernst Strüngmann Institute
External Affiliations:Univ Magdeburg, Dept Neurol, Leipziger Str 44, D-39120 Magdeburg, Germany Univ Magdeburg, Dept Neurol, D-39120 Magdeburg, Germany German Ctr Neurodegenerat Dis, D-39120 Magdeburg, Germany Brain Imaging Ctr Frankfurt, D-60528 Frankfurt, Germany Johannes Gutenberg Univ Mainz, Dept Neurol, D-55101 Mainz, Germany Max Planck Inst Brain Res, Dept Neurophysiol, D-60528 Frankfurt, Germany Ernst Strungmann Inst, D-60528 Frankfurt, Germany %G English
Identifiers:ISSN:1047-3211 %R http://dx.doi.org/10.1093/cercor/bhs0... [ID No:1]
URL:<Go to ISI>://WOS:000313529600008 [ID No:2]
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