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          Institute: MPI für Dynamik und Selbstorganisation     Collection: Biologische Physik und Evolutionäre Dynamik     Display Documents



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ID: 692208.0, MPI für Dynamik und Selbstorganisation / Biologische Physik und Evolutionäre Dynamik
Genomic evidence for ameiotic evolution in the bdelloid rotifer Adineta vaga
Authors:Flot, Jean-Francois; Hespeels, Boris; Li, Xiang; Noel, Benjamin; Arkhipova, Irina; Danchin, Etienne G. J.; Hejnol, Andreas; Henrissat, Bernard; Koszul, Romain; Aury, Jean-Marc; Barbe, Valerié; Bartélémy, Roxane-Marie; Bast, Jens; Bazykin, Georgii A.; Chabrol, Olivier; Couloux, Arnaud; Da Rocha, Martine; Da Silva, Corinne; Gladyshev, Eugene; Gouret, Philippe; Hallatschek, Oskar; Hecox-Lea, Bette; Labadie, Karine; Lejeune, Benjamin; Piskurek, Oliver; Poulain, Julie; Rodriguez, Fernando; Ryan, Joseph F.; Vakhrusheva, Olga A.; Wirth, Bénédicte; Yushenova, Irina; Kellis, Manolis; Kondrashov, Alexey S.; Mark Welch, David B.; Pontarotti, Pierre; Weissenbach, Jean; Wincker, Patrick; Jaillon, Olivier; Van Doninck, Karine; Wajnberg, Eric
Language:English
Date of Publication (YYYY-MM-DD):2013-07-21
Title of Journal:Nature
Journal Abbrev.:Nature
Volume:500
Issue / Number:7463
Start Page:453
End Page:457
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Loss of sexual reproduction is considered an evolutionary dead end for metazoans, but bdelloid rotifers challenge this view as they appear to have persisted asexually for millions of years1. Neither male sex organs nor meiosis have ever been observed in these microscopic animals: oocytes are formed through mitotic divisions, with no reduction of chromosome number and no indication of chromosome pairing2. However, current evidence does not exclude that they may engage in sex on rare, cryptic occasions. Here we report the genome of a bdelloid rotifer, Adineta vaga (Davis, 1873)3, and show that its structure is incompatible with conventional meiosis. At gene scale, the genome of A. vaga is tetraploid and comprises both anciently duplicated segments and less divergent allelic regions. However, in contrast to sexual species, the allelic regions are rearranged and sometimes even found on the same chromosome. Such structure does not allow meiotic pairing; instead, we find abundant evidence of gene conversion, which may limit the accumulation of deleterious mutations in the absence of meiosis. Gene families involved in resistance to oxidation, carbohydrate metabolism and defence against transposons are significantly expanded, which may explain why transposable elements cover only 3% of the assembled sequence. Furthermore, 8% of the genes are likely to be of non-metazoan origin and were probably acquired horizontally. This apparent convergence between bdelloids and prokaryotes sheds new light on the evolutionary significance of sex.
Free Keywords:Genome evolution
Evolutionary genetics
Evolutionary biology
External Publication Status:published
Document Type:Article
Communicated by:Folkert Müller-Hoissen
Affiliations:MPI für Dynamik und Selbstorganisation/Biologische Physik und Evolutionäre Dynamik
External Affiliations:University of Namur, Department of Biology, URBE, Laboratory of Evolutionary Genetics and Ecology, 5000 Namur, Belgium: Jean-François Flot, Boris Hespeels, Xiang Li, Benjamin Lejeune & Karine Van Doninck
Namur Research Institute for Life Sciences (NARILIS), 5000 Namur, Belgium: Jean-François Flot, Boris Hespeels, Xiang Li, Benjamin Lejeune & Karine Van Doninck
CEA-Institut de Génomique, GENOSCOPE, Centre National de Séquençage, 2 rue Gaston Crémieux, CP5706, 91057 Evry Cedex, France: Jean-François Flot, Benjamin Noel, Jean-Marc Aury, Valérie Barbe, Arnaud Couloux, Corinne Da Silva, Karine Labadie, Julie Poulain, Jean Weissenbach, Patrick Wincker & Olivier Jaillon
Université d’Evry, UMR 8030, CP5706, 91057 Evry Cedex, France: Jean-François Flot, Jean Weissenbach, Patrick Wincker & Olivier Jaillon
Centre National de la Recherche Scientifique (CNRS), UMR 8030, CP5706, 91057 Evry Cedex, France: Jean-François Flot, Jean Weissenbach, Patrick Wincker & Olivier Jaillon
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA: Irina Arkhipova, Eugene Gladyshev, Bette Hecox-Lea, Fernando Rodriguez, Irina Yushenova & David B. Mark Welch
INRA, UMR 1355 ISA, Institut Sophia Agrobiotech, 400 route des Chappes, 06903 Sophia-Antipolis, France: Etienne G. J. Danchin, Martine Da Rocha & Eric Wajnberg
CNRS, UMR 7254 ISA, Institut Sophia Agrobiotech, 400 route des Chappes, 06903 Sophia-Antipolis, France: Etienne G. J. Danchin, Martine Da Rocha & Eric Wajnberg
Université de Nice Sophia-Antipolis, UMR ISA, Institut Sophia Agrobiotech, 400 route des Chappes, 06903, Sophia-Antipolis, France: Etienne G. J. Danchin, Martine Da Rocha & Eric Wajnberg
Sars International Centre for Marine Molecular Biology, University of Bergen, 5008 Bergen, Norway: Andreas Hejnol & Joseph F. Ryan
Architecture et Fonction des Macromolécules Biologiques, Aix-Marseille University, CNRS UMR 7257, 13288 Marseille, France: Bernard Henrissat
Groupe Spatial regulation of genomes, CNRS UMR 3525, Department of Genomes and Genetics, Institut Pasteur, 75724 Paris, France: Romain Koszul
LATP UMR-CNRS 7353, Evolution Biologique et Modélisation, Aix-Marseille University, 13331 Marseille cedex 3, France: Roxane-Marie Barthélémy, Olivier Chabrol, Philippe Gouret, Bénédicte Wirth & Pierre Pontarotti
J.F. Blumenbach Institute of Zoology and Anthropology, University of Göttingen, 37073 Göttingen, Germany: Jens Bast
Department of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, Leninskye Gory 1-73, Moscow, 119991, Russia: Georgii A. Bazykin, Olga A. Vakhrusheva & Alexey S. Kondrashov
Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Bolshoi Karetny pereulok 19, Moscow, 127994, Russia: Georgii A. Bazykin & Olga A. Vakhrusheva
Department of Physics, University of California, Berkeley, California 94720, USA: Oskar Hallatschek
Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA: Bette Hecox-Lea
Courant Research Centre Geobiology, Georg-August-Universität Göttingen, Goldschmidtstraße 3, Göttingen 37077, Germany: Oliver Piskurek
MIT Computer Science and Artificial Intelligence Laboratory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA: Manolis Kellis & Olivier Jaillon
Life Sciences Institute and Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA: Alexey S. Kondrashov
Identifiers:DOI:10.1038/nature12326
URL:http://www.nature.com/nature/journal/v500/n7463/fu...
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