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          Institute: MPI für Dynamik und Selbstorganisation     Collection: Nichtlineare Dynamik     Display Documents

ID: 700602.0, MPI für Dynamik und Selbstorganisation / Nichtlineare Dynamik
Repetitive magnetic stimulation induces plasticity of excitatory postsynapses on proximal dendrites of cultured mouse CA1 pyramidal neurons
Authors:Lenz, Maximilian; Platschek, Steffen; Priesemann, Viola; Becker, Denise; Willems, Laurent M.; Ziemann, Ulf; Deller, Thomas; Müller-Dahlhaus, Florian; Jedlicka, Peter; Vlachos, Andreas
Date of Publication (YYYY-MM-DD):2014-08-10
Title of Journal:Brain Structure and Function
Start Page:1
End Page:15
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Repetitive transcranial magnetic stimulation (rTMS) of the human brain can lead to long-lasting changes in cortical excitability. However, the cellular and molecular mechanisms which underlie rTMS-induced plasticity remain incompletely understood. Here, we used repetitive magnetic stimulation (rMS) of mouse entorhinohippocampal slice cultures to study rMS-induced plasticity of excitatory postsynapses. By employing whole-cell patch-clamp recordings of CA1 pyramidal neurons, local electrical stimulations, immunostainings for the glutamate receptor subunit GluA1 and compartmental modeling, we found evidence for a preferential potentiation of excitatory synapses on proximal dendrites of CA1 neurons (2–4 h after stimulation). This rMS-induced synaptic potentiation required the activation of voltage-gated sodium channels, L-type voltage-gated calcium channels and N-methyl-D-aspartate-receptors. In view of these findings we propose a cellular model for the preferential strengthening of excitatory synapses on proximal dendrites following rMS in vitro, which is based on a cooperative effect of synaptic glutamatergic transmission and postsynaptic depolarization.
External Publication Status:published
Document Type:Article
Communicated by:Folkert Müller-Hoissen
Affiliations:MPI für Dynamik und Selbstorganisation/Nichtlineare Dynamik
External Affiliations:Institute of Clinical Neuroanatomy, Neuroscience Center,
Goethe-University Frankfurt, Theodor-Stern Kai 7,
60590 Frankfurt/Main, Germany
Department of Neurology and Stroke, and Hertie Institute for
Clinical Brain Research, Eberhard-Karls-University, Tuebingen, Germany
Department of Neural Systems and Coding, Max Planck Institute for Brain Research, Frankfurt/Main, Germany
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