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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 2 - Biochemistry (E. Izaurralde)     Display Documents



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ID: 705455.0, MPI für Entwicklungsbiologie / Abteilung 2 - Biochemistry (E. Izaurralde)
RNA binding by Hfq and ring-forming (L)Sm proteins: a trade-off between optimal sequence readout and RNA backbone conformation
Authors:Weichenrieder, O.
Date of Publication (YYYY-MM-DD):2014-05
Title of Journal:RNA Biology
Journal Abbrev.:RNA Biol
Volume:11
Issue / Number:5
Start Page:537
End Page:549
Sequence Number of Article:24828406
Review Status:Internal review
Audience:Experts Only
Abstract / Description:The eukaryotic Sm and the Sm-like (LSm) proteins form a large family that includes LSm proteins in archaea and the Hfq proteins in bacteria. Commonly referred to as the (L)Sm protein family, the various members play important roles in RNA processing, decay, and riboregulation. Particularly interesting from a structural point of view is their ability to assemble into doughnut-shaped rings, which allows them to bind preferentially the uridine-rich 3'-end of RNA oligonucleotides. With an emphasis on Hfq, this review compares the RNA-binding properties of the various (L)Sm rings that were recently co-crystallized with RNA substrates, and it discusses how these properties relate to physiological function.
External Publication Status:published
Document Type:Article
Communicated by:root
Affiliations:MPI für Entwicklungsbiologie/Abteilung 2 - Biochemie (Elisa Izaurralde)
Identifiers:ISSN:1555-8584 (Electronic) 1547-6286 (Linking) %R 10.4... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/24828406 [ID No:2]
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