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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 2 - Biochemistry (E. Izaurralde)     Display Documents



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ID: 705456.0, MPI für Entwicklungsbiologie / Abteilung 2 - Biochemistry (E. Izaurralde)
Dual-frequency calcium-responsive MRI agents
Authors:Kadjane, P.; Platas-Iglesias, C.; Boehm-Sturm, P.; Truffault, V.; Hagberg, G. E.; Hoehn, M.; Logothetis, N. K.; Angelovski, G.
Date of Publication (YYYY-MM-DD):2014-06-10
Title of Journal:Chemistry
Journal Abbrev.:Chemistry
Volume:20
Issue / Number:24
Start Page:7351
End Page:7362
Sequence Number of Article:24796323
Review Status:Internal review
Audience:Experts Only
Abstract / Description:Responsive or smart magnetic resonance imaging (MRI) contrast agents are molecular sensors that alter the MRI signal upon changes in a particular parameter in their microenvironment. Consequently, they could be exploited for visualization of various biochemical events that take place at molecular and cellular levels. In this study, a set of dual-frequency calcium-responsive MRI agents are reported. These are paramagnetic, fluorine-containing complexes that produce remarkably high MRI signal changes at the (1)H and (19)F frequencies at varying Ca(2+) concentrations. The nature of the processes triggered by Ca(2+) was revealed, allowing a better understanding of these complex systems and their further improvement. The findings indicate that these double-frequency tracers hold great promise for development of novel functional MRI methods.
External Publication Status:published
Document Type:Article
Communicated by:root
Affiliations:MPI für Entwicklungsbiologie/Abteilung 2 - Biochemie (Elisa Izaurralde)
Identifiers:ISSN:1521-3765 (Electronic) 0947-6539 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/24796323 [ID No:2]
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