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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2014 (arch)     Display Documents



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ID: 705654.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2014 (arch)
Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions.
Authors:Tapias, Alicia; Zhou, Zhong-Wei; Shi, Yue; Chong, Zechen; Wang, Pei; Groth, Marco; Platzer, Matthias; Huttner, Wieland; Herceg, Zdenko; Yang, Yun-Gui; Wang, Zhao-Qi
Date of Publication (YYYY-MM-DD):2014
Title of Journal:Cell Stem Cell
Volume:14
Issue / Number:5
Start Page:632
End Page:643
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Fate decisions in neural progenitor cells are orchestrated via multiple pathways, and the role of histone acetylation in these decisions has been ascribed to a general function promoting gene activation. Here, we show that the histone acetyltransferase (HAT) cofactor transformation/transcription domain-associated protein (Trrap) specifically regulates activation of cell-cycle genes, thereby integrating discrete cell-intrinsic programs of cell-cycle progression and epigenetic regulation of gene transcription in order to control neurogenesis. Deletion of Trrap impairs recruitment of HATs and transcriptional machinery specifically to E2F cell-cycle target genes, disrupting their transcription with consequent cell-cycle lengthening specifically within cortical apical neural progenitors (APs). Consistently, Trrap conditional mutants exhibit microcephaly because of premature differentiation of APs into intermediate basal progenitors and neurons, and overexpressing cell-cycle regulators in vivo can rescue these premature differentiation defects. These results demonstrate an essential and highly specific role for Trrap-mediated histone regulation in controlling cell-cycle progression and neurogenesis.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:thuem
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:5821
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