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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2014 (arch)     Display Documents

ID: 705665.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2014 (arch)
Motor regulation results in distal forces that bend partially disintegrated Chlamydomonas axonemes into circular arcs.
Authors:Mukundan, Vikram; Sartori, Pablo; Geyer, Veikko; Jülicher, Frank; Howard, Jonathon
Date of Publication (YYYY-MM-DD):2014
Title of Journal:Biophysical Journal
Issue / Number:11
Start Page:2434
End Page:2442
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The bending of cilia and flagella is driven by forces generated by dynein motor proteins. These forces slide adjacent microtubule doublets within the axoneme, the motile cytoskeletal structure. To create regular, oscillatory beating patterns, the activities of the axonemal dyneins must be coordinated both spatially and temporally. It is thought that coordination is mediated by stresses or strains, which build up within the moving axoneme, and somehow regulate dynein activity. During experimentation with axonemes subjected to mild proteolysis, we observed pairs of doublets associating with each other and forming bends with almost constant curvature. By modeling the statics of a pair of filaments, we show that the activity of the motors concentrates at the distal tips of the doublets. Furthermore, we show that this distribution of motor activity accords with models in which curvature, or curvature-induced normal forces, regulates the activity of the motors. These observations, together with our theoretical analysis, provide evidence that dynein activity can be regulated by curvature or normal forces, which may, therefore, play a role in coordinating the beating of cilia and flagella.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:thuem
Affiliations:MPI für molekulare Zellbiologie und Genetik
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