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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2014 (arch)     Display Documents



ID: 705772.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2014 (arch)
Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death.
Authors:Neumann, Konstantin; Castiñeiras-Vilariño, Mercedes; Höckendorf, Ulrike; Hannesschläger, Nicole; Lemeer, Simone; Kupka, Danny; Meyermann, Svenia; Lech, Maciej; Anders, Hans-Joachim; Kuster, Bernhard; Busch, Dirk H; Gewies, Andreas; Naumann, Ronald; Groß, Olaf; Ruland, Jurgen
Date of Publication (YYYY-MM-DD):2014
Title of Journal:Immunity
Volume:40
Issue / Number:3
Start Page:389
End Page:399
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Recognition of cell death by the innate immune system triggers inflammatory responses. However, how these reactions are regulated is not well understood. Here, we identify the inhibitory C-type lectin receptor Clec12a as a specific receptor for dead cells. Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate, MSU), which are key danger signals for cell-death-induced immunity. Clec12a inhibited inflammatory responses to MSU in vitro, and Clec12a-deficient mice exhibited hyperinflammatory responses after being challenged with MSU or necrotic cells and after radiation-induced thymocyte killing in vivo. Thus, we identified a negative regulatory MSU receptor that controls noninfectious inflammation in response to cell death that has implications for autoimmunity and inflammatory disease.
External Publication Status:published
Document Type:Article
Communicated by:thuem
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:5677
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