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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2014 (arch)     Display Documents



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ID: 705789.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2014 (arch)
Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development.
Authors:Rodenfels, Jonathan; Lavrynenko, Oksana; Ayciriex, Sophie; Sampaio, Julio; Carvalho, Maria; Shevchenko, Andrej; Eaton, Suzanne
Date of Publication (YYYY-MM-DD):2014
Title of Journal:Genes & Development
Volume:28
Issue / Number:23
Start Page:2636
End Page:2651
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes are far from understood. Here, we show that the intestine responds to nutrient availability by regulating production of a circulating lipoprotein-associated form of the signaling protein Hedgehog (Hh). Levels of circulating Hh tune the rates of growth and developmental timing in a coordinated fashion. Circulating Hh signals to the fat body to control larval growth. It regulates developmental timing by controlling ecdysteroid production in the prothoracic gland. Circulating Hh is especially important during starvation, when it is also required for mobilization of fat body triacylglycerol (TAG) stores. Thus, we demonstrate that Hh, previously known only for its local morphogenetic functions, also acts as a lipoprotein-associated endocrine hormone, coordinating the response of multiple tissues to nutrient availability.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:thuem
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:5916
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