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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents

ID: 706237.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
Neuronal connectome of a sensory-motor circuit for visual navigation
Authors:Randel, N.; Asadulina, A.; Bezares-Calderon, L. A.; Veraszto, C.; Williams, E. A.; Conzelmann, M.; Shahidi, R.; Jekely, G.
Date of Publication (YYYY-MM-DD):2014-05-27
Title of Journal:eLife
Journal Abbrev.:Elife
Start Page:e02730
Sequence Number of Article:24867217
Review Status:Internal review
Audience:Experts Only
Abstract / Description:Animals use spatial differences in environmental light levels for visual navigation; however, how light inputs are translated into coordinated motor outputs remains poorly understood. Here we reconstruct the neuronal connectome of a four-eye visual circuit in the larva of the annelid Platynereis using serial-section transmission electron microscopy. In this 71-neuron circuit, photoreceptors connect via three layers of interneurons to motorneurons, which innervate trunk muscles. By combining eye ablations with behavioral experiments, we show that the circuit compares light on either side of the body and stimulates body bending upon left-right light imbalance during visual phototaxis. We also identified an interneuron motif that enhances sensitivity to different light intensity contrasts. The Platynereis eye circuit has the hallmarks of a visual system, including spatial light detection and contrast modulation, illustrating how image-forming eyes may have evolved via intermediate stages contrasting only a light and a dark field during a simple visual task.
Free Keywords:Platynereis; annelid; connectomics; eye evolution; neuroscience; phototaxis; platynereis dumerilii
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen/Arbeitsgruppe Jekely
Identifiers:ISSN:2050-084X (Electronic) 2050-084X (Linking) %R 10.7... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/24867217 [ID No:2]
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