Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents



  history
ID: 706237.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
Neuronal connectome of a sensory-motor circuit for visual navigation
Authors:Randel, N.; Asadulina, A.; Bezares-Calderon, L. A.; Veraszto, C.; Williams, E. A.; Conzelmann, M.; Shahidi, R.; Jekely, G.
Date of Publication (YYYY-MM-DD):2014-05-27
Title of Journal:eLife
Journal Abbrev.:Elife
Volume:3
Start Page:e02730
Sequence Number of Article:24867217
Review Status:Internal review
Audience:Experts Only
Abstract / Description:Animals use spatial differences in environmental light levels for visual navigation; however, how light inputs are translated into coordinated motor outputs remains poorly understood. Here we reconstruct the neuronal connectome of a four-eye visual circuit in the larva of the annelid Platynereis using serial-section transmission electron microscopy. In this 71-neuron circuit, photoreceptors connect via three layers of interneurons to motorneurons, which innervate trunk muscles. By combining eye ablations with behavioral experiments, we show that the circuit compares light on either side of the body and stimulates body bending upon left-right light imbalance during visual phototaxis. We also identified an interneuron motif that enhances sensitivity to different light intensity contrasts. The Platynereis eye circuit has the hallmarks of a visual system, including spatial light detection and contrast modulation, illustrating how image-forming eyes may have evolved via intermediate stages contrasting only a light and a dark field during a simple visual task.
Free Keywords:Platynereis; annelid; connectomics; eye evolution; neuroscience; phototaxis; platynereis dumerilii
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen/Arbeitsgruppe Jekely
Identifiers:ISSN:2050-084X (Electronic) 2050-084X (Linking) %R 10.7... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/24867217 [ID No:2]
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.