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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents



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ID: 706245.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
Evolutionary relationship of two ancient protein superfolds
Authors:Farias-Rico, J. A.; Schmidt, S.; Hocker, B.
Date of Publication (YYYY-MM-DD):2014-09
Title of Journal:Nature Chemical Biology
Journal Abbrev.:Nat Chem Biol
Volume:10
Issue / Number:9
Start Page:710
End Page:715
Sequence Number of Article:25038785
Review Status:Internal review
Audience:Experts Only
Abstract / Description:Proteins are the molecular machines of the cell that fold into specific three-dimensional structures to fulfill their functions. To improve our understanding of how the structure and function of proteins arises, it is crucial to understand how evolution has generated the structural diversity we observe today. Classically, proteins that adopt different folds are considered to be nonhomologous. However, using state-of-the-art tools for homology detection, we found evidence of homology between proteins of two ancient and highly populated protein folds, the (betaalpha)8-barrel and the flavodoxin-like fold. We detected a family of sequences that show intermediate features between both folds and determined what is to our knowledge the first representative crystal structure of one of its members, giving new insights into the evolutionary link of two of the earliest folds. Our findings contribute to an emergent vision where protein superfolds share common ancestry and encourage further approaches to complete the mapping of structure space onto sequence space.
Free Keywords:Amino Acid Sequence; Biological Evolution; Conserved Sequence; Crystallography, X-Ray; *Evolution, Molecular; Flavodoxin/chemistry; Models, Molecular; Molecular Sequence Data; Peptide Mapping; *Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins/*chemistry; Sequence Homology
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen/Arbeitsgruppe Höcker
Identifiers:ISSN:1552-4469 (Electronic) 1552-4450 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/25038785 [ID No:2]
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