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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents



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ID: 706661.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
Species-wide genetic incompatibility analysis identifies immune genes as hot spots of deleterious epistasis
Authors:Chae, E.; Bomblies, K.; Kim, S. T.; Karelina, D.; Zaidem, M.; Ossowski, S.; Martin-Pizarro, C.; Laitinen, R. A.; Rowan, B. A.; Tenenboim, H.; Lechner, S.; Demar, M.; Habring-Muller, A.; Lanz, C.; Ratsch, G.; Weigel, D.
Date of Publication (YYYY-MM-DD):2014-12-04
Title of Journal:Cell
Journal Abbrev.:Cell
Volume:159
Issue / Number:6
Start Page:1341
End Page:1351
Sequence Number of Article:25467443
Review Status:Internal review
Audience:Experts Only
Abstract / Description:Intraspecific genetic incompatibilities prevent the assembly of specific alleles into single genotypes and influence genome- and species-wide patterns of sequence variation. A common incompatibility in plants is hybrid necrosis, characterized by autoimmune responses due to epistatic interactions between natural genetic variants. By systematically testing thousands of F1 hybrids of Arabidopsis thaliana strains, we identified a small number of incompatibility hot spots in the genome, often in regions densely populated by nucleotide-binding domain and leucine-rich repeat (NLR) immune receptor genes. In several cases, these immune receptor loci interact with each other, suggestive of conflict within the immune system. A particularly dangerous locus is a highly variable cluster of NLR genes, DM2, which causes multiple independent incompatibilities with genes that encode a range of biochemical functions, including NLRs. Our findings suggest that deleterious interactions of immune receptors limit the combinations of favorable disease resistance alleles accessible to plant genomes.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)
External Affiliations:Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany; Friedrich Miescher Laboratory, Max Planck Society, 72076 Tubingen, Germany. Friedrich Miescher Laboratory, Max Planck Society, 72076 Tubingen, Germany. Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany. Electronic address: weigel@weigelworld.org.
Identifiers:ISSN:1097-4172 (Electronic) 0092-8674 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/25467443 [ID No:2]
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