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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 4 - Evolutionary Biology (R. Sommer)     Display Documents



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ID: 708674.0, MPI für Entwicklungsbiologie / Abteilung 4 - Evolutionary Biology (R. Sommer)
Strongyloides stercoralis genotypes in humans in Cambodia
Authors:Schar, F.; Guo, L.; Streit, A.; Khieu, V.; Muth, S.; Marti, H.; Odermatt, P.
Date of Publication (YYYY-MM-DD):2014-06
Title of Journal:Parasitology International
Journal Abbrev.:Parasitol Int
Volume:63
Issue / Number:3
Start Page:533
End Page:536
Sequence Number of Article:24530857
Review Status:Internal review
Audience:Experts Only
Abstract / Description:Little is known about the genetic variability of the soil-transmitted nematode, Strongyloides stercoralis, in humans. We sequenced portions of the small subunit rDNA (SSU), including the hyper variable regions (HVR) I and IV from S. stercoralis larvae derived from individuals living in a rural setting in Cambodia. We identified three polymorphic positions, including a previously reported one within the HVR I. HVR IV was invariable. Six different SSU alleles existed in our sample. Although different genotypes of S. stercoralis were found in the same individuals, no heterozygous larvae were found. This indicates that there is no or very little interbreeding between the different genotypes. Further studies are needed to examine if this is because sexual reproduction, which is facultative, is rare in our study area's S. stercoralis population or because what is considered to be S. stercoralis today is actually a complex of closely related species or subspecies.
Free Keywords:Animals; Base Sequence; Cambodia/epidemiology; DNA, Helminth/genetics/metabolism; Female; Genotype; Humans; Larva; Molecular Sequence Data; RNA, Ribosomal, 18S/genetics/metabolism; Strongyloides stercoralis/classification/*genetics/isolation & purification; Strongyloidiasis/epidemiology/*parasitology
External Publication Status:published
Document Type:Article
Communicated by:MPI für Entwickungsbiologie
Affiliations:MPI für Entwicklungsbiologie/Abteilung 4 - Evolutionsbiologie (Ralf J. Sommer)
External Affiliations:Department for Evolutionary Biology, Max-Planck-Institute for Developmental Biology, Tuebingen, Germany. Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; National Center for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia. National Center for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia. University of Basel, Basel, Switzerland; Medical and Diagnostics Department, Swiss Tropical and Public Health Institute, Basel, Switzerland. Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address: peter.odermatt@unibas.ch.
Identifiers:ISSN:1873-0329 (Electronic) 1383-5769 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/24530857 [ID No:2]
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