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          Institute: MPI für bioanorganische Chemie     Collection: MPI für bioanorganische Chemie     Display Documents



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ID: 708709.0, MPI für bioanorganische Chemie / MPI für bioanorganische Chemie
Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of membrane type 1 matrix metalloproteinase.
Authors:Ogata, Hideaki; Decaneto, Elena; Grossman, M.; Havenith, Martina; Sagi, I.; Lubitz, Wolfgang; Knipp, Markus
Language:English
Date of Publication (YYYY-MM-DD):2014
Title of Journal:Acta Crystallographica Section F-Structural Biology and Crystallization Communications
Journal Abbrev.:Acta.Cryst.F
Volume:70
Start Page:232
End Page:235
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Membrane type 1 matrix metalloproteinase (MT1-MMP) belongs to the large family of zinc-dependent endopeptidases termed MMPs that are located in the extracellular matrix. MT1-MMP was crystallized at 277 K using the vapour-diffusion method with PEG as a precipitating agent. Data sets for MT1-MMP were collected to 2.24 angstrom resolution at 100 K. The crystals belonged to space group P4(3)2(1)2, with unit-cell parameters a = 62.99, c = 122.60 angstrom. The crystal contained one molecule per asymmetric unit, with a Matthews coefficient (V-M) of 2.90 angstrom(3) Da(-1); the solvent content is estimated to be 57.6%.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für bioanorganische Chemie
External Affiliations:[ Havenith,M.; ]Ruhr Univ Bochum, D-44801 Bochum, Germany.
[ Grossman,M.;Sagi,I.; ] Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel.
Identifiers:ISI:000332229200018 [ID No:1]
ISSN:1744-3091 [ID No:2]
DOI:10.1107/S2053230X13034857
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