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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook_2015     Display Documents



ID: 711877.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook_2015
HMGA proteins as modulators of chromatin structure during transcriptional activation
Authors:Ozturk, N.; Singh, I.; Mehta, A.; Braun, T.; Barreto, G.
Date of Publication (YYYY-MM-DD):2014
Title of Journal:Front Cell Dev Biol
Volume:2
Start Page:5
Audience:Not Specified
Abstract / Description:High mobility group (HMG) proteins are the most abundant non-histone chromatin associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of chromatin locally and globally. Accessibility to DNA within chromatin is a central factor that affects DNA-dependent nuclear processes, such as transcription, replication, recombination, and repair. HMG proteins associate with different multi-protein complexes to regulate these processes by mediating accessibility to DNA. HMG proteins can be subdivided into three families: HMGA, HMGB, and HMGN. In this review, we will focus on recent advances in understanding the function of HMGA family members, specifically their role in gene transcription regulation during development and cancer.
External Publication Status:published
Document Type:Article
Communicated by:MPI für Herz- und Lungenforschung
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research Bad Nauheim, Germany. %^ 1435822261
Identifiers:ISSN:2296-634X (Electronic) 2296-634X (Linking) %R 10.3389/fcell.2014.00005
URL:http://www.ncbi.nlm.nih.gov/pubmed/25364713
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