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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook_2015     Display Documents



ID: 711915.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook_2015
Systematic aging of degradable nanosuspension ameliorates vibrating-mesh nebulizer performance
Authors:Dalla-Bona, A. C.; Schmehl, T.; Gessler, T.; Seeger, W.; Beck-Broichsitter, M.
Date of Publication (YYYY-MM-DD):2014-12-18
Title of Journal:Drug Dev Ind Pharm
Start Page:1
End Page:6
Audience:Not Specified
Abstract / Description:Abstract Context: The process of vibrating-mesh nebulization is affected by sample physicochemical properties. Exemplary, electrolyte supplementation of diverse formulations facilitated the delivery of adequate aerosols for deep lung deposition. Objective: This study addressed the impact of storage conditions of poly(lactide-co-glycolide) nanosuspension on aerosol properties when nebulized by the eFlow(R)rapid. Materials and methods: First, purified nanosuspensions were supplemented with electrolytes (i.e. sodium chloride, lactic and glycolic acid). Second, the degradable nanoparticles (NP) were incubated at different temperatures (i.e. 4, 22 and 36 degrees C) for up to two weeks. The effect of formulation supplementation and storage on aerosol characteristics was studied by laser diffraction and correlated with the sample conductivity. Results and discussion: Nebulization of purified nanosuspensions resulted in droplet diameters of >7.0 microm. However, electrolyte supplementation and storage, which led to an increase in sample conductivity (>10-20 microS/cm), were capable of providing smaller droplet diameters during vibrating-mesh nebulization (</=5.0 microm). No relevant change of NP properties (i.e. size, morphology, remaining mass and molecular weight of the employed polymer) was observed when incubated at 22 degrees C for two weeks. Conclusion: Sample aging is an alternative to electrolyte supplementation in order to ameliorate the aerosol characteristics of degradable NP formulations when nebulized by vibrating-mesh technology.
Free Keywords:Aerosol; hydrolytic degradation; nanoparticles; poly(lactide-co-glycolide); pulmonary drug delivery; vibrating-mesh nebulizer
External Publication Status:published
Document Type:Article
Communicated by:MPI für Herz- und Lungenforschung
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:%^ 1435822045
Identifiers:ISSN:1520-5762 (Electronic) 0363-9045 (Linking) %R 10.3109/03639045.2014.993399
URL:http://www.ncbi.nlm.nih.gov/pubmed/25519975
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