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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook_2015     Display Documents



ID: 711921.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook_2015
RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-alpha in cardiac ischaemia/reperfusion injury
Authors:Cabrera-Fuentes, H. A.; Ruiz-Meana, M.; Simsekyilmaz, S.; Kostin, S.; Inserte, J.; Saffarzadeh, M.; Galuska, S. P.; Vijayan, V.; Barba, I.; Barreto, G.; Fischer, S.; Lochnit, G.; Ilinskaya, O. N.; Baumgart-Vogt, E.; Boning, A.; Lecour, S.; Hausenloy, D. J.; Liehn, E. A.; Garcia-Dorado, D.; Schluter, K. D.; Preissner, K. T.
Date of Publication (YYYY-MM-DD):2014-12
Title of Journal:Thromb Haemost
Volume:112
Issue / Number:6
Start Page:1110
End Page:1119
Audience:Not Specified
Abstract / Description:Despite optimal therapy, the morbidity and mortality of patients presenting with an acute myocardial infarction (MI) remain significant, and the initial mechanistic trigger of myocardial "ischaemia/reperfusion (I/R) injury" remains greatly unexplained. Here we show that factors released from the damaged cardiac tissue itself, in particular extracellular RNA (eRNA) and tumour-necrosis-factor alpha (TNF-alpha), may dictate I/R injury. In an experimental in vivo mouse model of myocardial I/R as well as in the isolated I/R Langendorff-perfused rat heart, cardiomyocyte death was induced by eRNA and TNF-alpha. Moreover, TNF-alpha promoted further eRNA release especially under hypoxia, feeding a vicious cell damaging cycle during I/R with the massive production of oxygen radicals, mitochondrial obstruction, decrease in antioxidant enzymes and decline of cardiomyocyte functions. The administration of RNase1 significantly decreased myocardial infarction in both experimental models. This regimen allowed the reduction in cytokine release, normalisation of antioxidant enzymes as well as preservation of cardiac tissue. Thus, RNase1 administration provides a novel therapeutic regimen to interfere with the adverse eRNA-TNF-alpha interplay and significantly reduces or prevents the pathological outcome of ischaemic heart disease.
Free Keywords:Inflammatory mediators; cardiology; cytokines; ischaemic heart disease
External Publication Status:published
Document Type:Article
Communicated by:MPI für Herz- und Lungenforschung
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:%^ 1435825371
Identifiers:ISSN:0340-6245 (Print) 0340-6245 (Linking) %R 10.1160/TH14-08-0703
URL:http://www.ncbi.nlm.nih.gov/pubmed/25354936
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