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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook_2015     Display Documents



ID: 711928.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook_2015
On the correlation of output rate and aerodynamic characteristics in vibrating-mesh-based aqueous aerosol delivery
Authors:Beck-Broichsitter, M.; Oesterheld, N.; Knuedeler, M. C.; Seeger, W.; Schmehl, T.
Date of Publication (YYYY-MM-DD):2014-01-30
Title of Journal:Int J Pharm
Volume:461
Issue / Number:1-2
Start Page:34
End Page:37
Audience:Not Specified
Abstract / Description:Aerosolization of aqueous formulations is of special interest for inhalative drug delivery, where an adequate nebulizer performance represents a prerequisite for improving pulmonary therapy. The present study investigated the interplay of output rate and aerodynamic characteristics of different excipient-based formulations and its impact on the atomization process by vibrating-mesh technology (i.e. eFlow((R))rapid). Output rate and aerodynamic characteristics were manipulated by both dynamic viscosity and conductivity of the applied formulation. Supplementation with sucrose and sodium chloride caused a decline (down to approximately 0.2 g/min) and elevation (up to approximately 1.0 g/min) of the nebulizer output rate, respectively. However, both excipients were capable of decreasing the aerodynamic diameter of produced aerosol droplets from >7.0 mum to values of </=5.0 mum. Thus, the correlation of output rate and aerodynamic characteristics resulted in linear fits of opposite slopes (R(2)>0.85). Finally, the overall number of delivered aerosol droplets per time was almost constant for sucrose (</=1x10(8) droplets/s), while for sodium chloride a concentration-dependent increase was observed (up to approximately 3x10(8) droplets/s). Overall, the current findings illustrated the influence of formulation parameters on the aerosolization process performed by vibrating-mesh technology. Moreover, concentration and charge distribution of aerosol populations supposedly modify the final characteristics of the delivered aerosols.
Free Keywords:Aerodynamic diameter; Aerosol coagulation; Output rate; Pulmonary drug delivery; Vibrating-mesh nebulizer
External Publication Status:published
Document Type:Article
Communicated by:MPI für Herz- und Lungenforschung
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Medical Clinic II, Department of Internal Medicine, Justus-Liebig-Universitat, Giessen, Germany. %^ 1435822045
Identifiers:ISSN:1873-3476 (Electronic) 0378-5173 (Linking) %R 10.1016/j.ijpharm.2013.11.036
URL:http://www.ncbi.nlm.nih.gov/pubmed/24291081
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