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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook_2015     Display Documents

ID: 711931.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook_2015
Polymer nanoparticle-based controlled pulmonary drug delivery
Authors:Beck-Broichsitter, M.; Dalla-Bona, A. C.; Kissel, T.; Seeger, W.; Schmehl, T.
Date of Publication (YYYY-MM-DD):2014
Title of Journal:Methods Mol Biol
Start Page:133
End Page:145
Audience:Not Specified
Abstract / Description:The development of novel formulations for controlled pulmonary drug delivery purposes has gained remarkable interest in medicine. Although nanomedicine represents attractive concepts for the treatment of numerous systemic diseases, scant information is available on the controlled drug release characteristics of colloidal formulations following lung administration, which might be attributed to the lack of methods to follow their absorption and distribution behavior in the pulmonary environment.In this chapter, we describe the methods of preparation and characterization of drug-loaded polymeric nanoparticles prepared from biodegradable charge-modified branched polyesters, aerosolization of the nanosuspensions using a vibrating-mesh nebulizer, and evaluation of the pulmonary pharmacokinetics (i.e., absorption and distribution characteristics) of the nanoscale drug delivery vehicles following aerosol delivery to the airspace of an isolated lung model. The disclosed methodology may contribute to the design of advanced colloids for the treatment of respiratory disorders.
Free Keywords:Administration, Inhalation; Aerosols; Animals; Colloids; Delayed-Action Preparations/chemistry/*pharmacokinetics; Drug Compounding/methods; Drug Liberation; Fluoresceins/*pharmacokinetics; Lung/*drug effects/physiology; Nanoparticles/*chemistry; Nebulizers and Vaporizers; Organ Culture Techniques; Particle Size; Polyglactin 910/*analogs & derivatives/chemistry; Polyvinyl Alcohol/*chemistry; Rabbits
External Publication Status:published
Document Type:Article
Communicated by:MPI für Herz- und Lungenforschung
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:%^ 1435822045
Identifiers:ISSN:1940-6029 (Electronic) 1064-3745 (Linking) %R 10.1007/978-1-4939-0363-4_8
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