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          Institute: MPI für bioanorganische Chemie     Collection: MPI für bioanorganische Chemie     Display Documents

ID: 713112.0, MPI für bioanorganische Chemie / MPI für bioanorganische Chemie
A Redox Hydrogel Protects the O2 Sensitive [FeFe]-Hydrogenase from Chlamydomonas reinhardtii from Oxidative Damage
Authors:Oughli, Alaa Alsheikh; Conzuelo, Felipe; Winkler, Martin; Happe, Thomas; Lubitz, Wolfgang; Schuhmann, Wolfgang; Rüdiger, Olaf; Plumere, Nicolas
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Angewandte Chemie-International Edition
Journal Abbrev.:Angew. Chem. Int. Ed.
Issue / Number:42 Sp. Iss. SI
Start Page:12329
End Page:12333
Review Status:Internal review
Audience:Experts Only
Abstract / Description:The integration of sensitive catalysts in redox matrices opens up the possibility for their protection from deactivating molecules such as O-2. [FeFe]-hydrogenases are enzymes catalyzing H-2 oxidation/production which are irreversibly deactivated by O-2. Therefore, their use under aerobic conditions has never been achieved. Integration of such hydrogenases in viologen-modified hydrogel films allows the enzyme to maintain catalytic current for H-2 oxidation in the presence of O-2, demonstrating a protection mechanism independent of reactivation processes. Within the hydrogel, electrons from the hydrogenase-catalyzed H-2 oxidation are shuttled to the hydrogel-solution interface for O-2 reduction. Hence, the harmful O-2 molecules do not reach the hydrogenase. We illustrate the potential applications of this protection concept with a biofuel cell under H-2/O-2 mixed feed.
Comment of the Author/Creator:Date: 2015, OCT 12 2015
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:N. N.
Affiliations:MPI für bioanorganische Chemie
External Affiliations:[Conzuelo,F.; Schuhmann,W.] Ruhr Univ.Bochum, Analyt.Chem.Ctr.Elect.Sci. CES, D-44780 Bochum, Germany.
[Winkler,M.; Happe,T.; ] Ruhr Univ.Bochum, Lehrstuhl Biochem.Pflanzen, AG Photobiotechnol., D-44801 Bochum, Germany.
[Plumere,N.] Ruhr Univ.Bochum, Ctr.Electrochem.Sci.Mol. Nanostruct., D-44780 Bochum, Germany.
Identifiers:ISI:000363397300011 [ID No:1]
ISSN:1433-7851 [ID No:2]
DOI:10.1002/anie.201502776 [ID No:3]
DOI:10.1002/ange.201502776 [ID No:4]
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