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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2016 (publ. 2015, arch)     Display Documents



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ID: 717249.0, MPI für molekulare Biomedizin / Jahrbuch 2016 (publ. 2015, arch)
Integrin beta1 controls VE-cadherin localization and blood vessel stability
Authors:Yamamoto, H.; Ehling, M.; Kato, K.; Kanai, K.; van Lessen, M.; Frye, M.; Zeuschner, D.; Nakayama, M.; Vestweber, D.; Adams, R. H.
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Nat Commun
Volume:6
Start Page:6429
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Angiogenic blood vessel growth requires several distinct but integrated cellular activities. Endothelial cell sprouting and proliferation lead to the expansion of the vasculature and give rise to a highly branched, immature plexus, which is subsequently reorganized into a mature and stable network. Although it is known that integrin-mediated cell-matrix interactions are indispensable for embryonic angiogenesis, little is known about the function of integrins in different steps of vascular morphogenesis. Here, by investigating the integrin beta1-subunit with inducible and endothelial-specific gene targeting in the postnatal mouse retina, we show that beta1 integrin promotes endothelial sprouting but is a negative regulator of proliferation. In maturing vessels, integrin beta1 is indispensable for proper localization of VE-cadherin and thereby cell-cell junction integrity. The sum of our findings establishes that integrin beta1 has critical functions in the growing and maturing vasculature, and is required for the formation of stable, non-leaky blood vessels.
Free Keywords:Animals; Antigens, CD/*metabolism; Antigens, CD29/*metabolism; Blotting, Western; Brain/anatomy & histology; Cadherins/*metabolism; Cell Proliferation; Endothelium/*growth & development/metabolism; Gene Targeting; Image Processing, Computer-Assisted; Immunohistochemistry; Immunoprecipitation; Intercellular Junctions/metabolism/*physiology; Mice; Microscopy, Electron; Morphogenesis/*physiology; Neovascularization, Physiologic/*physiology; RNA, Small Interfering/genetics; Real-Time Polymerase Chain Reaction; Retinal Vessels/*growth & development/ultrastructure
External Publication Status:published
Document Type:Article
Communicated by:Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Rontgenstrasse 20, D-48149 Munster, Germany. Electron Microscopy Unit, Max Planck Institute for Molecular Biomedicine, Rontgenstrasse 20, D-48149 Munster, Germany.
Identifiers:ISSN:2041-1723 (Electronic) 2041-1723 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/25752958 [ID No:2]
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