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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2016 (publ. 2015, arch)     Display Documents

ID: 717280.0, MPI für molekulare Biomedizin / Jahrbuch 2016 (publ. 2015, arch)
Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization
Authors:Nunan, R.; Campbell, J.; Mori, R.; Pitulescu, M. E.; Jiang, W. G.; Harding, K. G.; Adams, R. H.; Nobes, C. D.; Martin, P.
Date of Publication (YYYY-MM-DD):2015-11-17
Title of Journal:Cell Rep
Issue / Number:7
Start Page:1380
End Page:1395
Review Status:Internal review
Audience:Not Specified
Abstract / Description:For a skin wound to successfully heal, the cut epidermal-edge cells have to migrate forward at the interface between scab and healthy granulation tissue. Much is known about how lead-edge cells migrate, but very little is known about the mechanisms that enable active participation by cells further back. Here we show that ephrin-B1 and its receptor EphB2 are both upregulated in vivo, just for the duration of repair, in the first 70 or so rows of epidermal cells, and this signal leads to downregulation of the molecular components of adherens and tight (but not desmosomal) junctions, leading to loosening between neighbors and enabling shuffle room among epidermal cells. Additionally, this signaling leads to the shutdown of actomyosin stress fibers in these same epidermal cells, which may act to release tension within the wound monolayer. If this signaling axis is perturbed, then disrupted healing is a consequence in mouse and man.
External Publication Status:published
Document Type:Article
Communicated by:Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Schools of Biochemistry and Physiology & Pharmacology, University of Bristol, Bristol BS8 1TD, UK; Department of Pathology, Nagasaki University, Nagasaki 852-8523, Japan. Max Planck Institute for Molecular Biomedicine, 48149 Muenster, Germany; Faculty of Medicine, University of Muenster, 48149 Muenster, Germany. School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Schools of Biochemistry and Physiology & Pharmacology, University of Bristol, Bristol BS8 1TD, UK; School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address: paul.martin@bristol.ac.uk.
Identifiers:ISSN:2211-1247 (Electronic) %R 10.1016/j.celrep.2015.09... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/26549443 [ID No:2]
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