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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2016 (publ. 2015, arch)     Display Documents



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ID: 717301.0, MPI für molekulare Biomedizin / Jahrbuch 2016 (publ. 2015, arch)
The BAFFling function of Syk in B-cell homeostasis
Authors:Konigsberger, S.; Kiefer, F.
Date of Publication (YYYY-MM-DD):2015-04-01
Title of Journal:EMBO J
Volume:34
Issue / Number:7
Start Page:838
End Page:840
Review Status:Internal review
Audience:Not Specified
Abstract / Description:The TNF receptor family member BAFFR is essential for providing mature B cells with pro-survival signals and has recently been claimed to transduce these, though not exclusively, via a Syk-dependent signaling hub that feeds into ERK/AKT activation. In this issue of The EMBO Journal, Hobeika et al (2015) describe a synergistic prosurvival scenario involving BAFFR and CD19, which remains functional under Syk null conditions and is able to maintain mature B-cell survival. The authors hence propose a BAFFR-/CD19-driven mechanism to act in parallel with homeostatic NF-kappaB/AKT activation in non-stimulated B cells.
Free Keywords:Animals; Antigens, CD19/*immunology; B-Cell Activation Factor Receptor/immunology; B-Lymphocytes/*immunology; Intracellular Signaling Peptides and Proteins/*immunology; Protein-Tyrosine Kinases/*immunology; Signal Transduction/*immunology
External Publication Status:published
Document Type:Article
Communicated by:Keuker
Affiliations:MPI für molekulare Biomedizin
Identifiers:ISSN:1460-2075 (Electronic) 0261-4189 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/25712210 [ID No:2]
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