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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2016 (publ. 2015, arch)     Display Documents



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ID: 717310.0, MPI für molekulare Biomedizin / Jahrbuch 2016 (publ. 2015, arch)
The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis
Authors:Helker, C. S.; Schuermann, A.; Pollmann, C.; Chng, S. C.; Kiefer, F.; Reversade, B.; Herzog, W.
Date of Publication (YYYY-MM-DD):2015
Title of Journal:eLife
Volume:4
Review Status:Internal review
Audience:Not Specified
Abstract / Description:A key step in the de novo formation of the embryonic vasculature is the migration of endothelial precursors, the angioblasts, to the position of the future vessels. To form the first axial vessels, angioblasts migrate towards the midline and coalesce underneath the notochord. Vascular endothelial growth factor has been proposed to serve as a chemoattractant for the angioblasts and to regulate this medial migration. Here we challenge this model and instead demonstrate that angioblasts rely on their intrinsic expression of Apelin receptors (Aplr, APJ) for their migration to the midline. We further show that during this angioblast migration Apelin receptor signaling is mainly triggered by the recently discovered ligand Elabela (Ela). As neither of the ligands Ela or Apelin (Apln) nor their receptors have previously been implicated in regulating angioblast migration, we hereby provide a novel mechanism for regulating vasculogenesis, with direct relevance to physiological and pathological angiogenesis.
Free Keywords:Animals; Cell Movement/*physiology; Chemokines/*metabolism; Cloning, Molecular; DNA Primers/genetics; Endothelial Cells/*cytology; Endothelial Progenitor Cells/metabolism/*physiology; Humans; In Situ Hybridization; *Models, Biological; Mutagenesis; Neovascularization, Physiologic/*physiology; Zebrafish; Zebrafish Proteins/*metabolism; Vegf; angioblast migration; chemoattractant; developmental biology; dorsal aorta; endothelial cell migration; human biology; medicine; notochord; stem cells
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Max Planck Institute for Molecular Biomedicine, Muenster, Germany. Institute of Medical Biology, Human Genetics and Embryology Laboratory, A*STAR, Singapore, Singapore.
Identifiers:ISSN:2050-084X (Electronic) 2050-084X (Linking) %R 10.7... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/26017639 [ID No:2]
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