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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2015 (arch)     Display Documents



ID: 717959.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2015 (arch)
Systematic imaging reveals features and changing localization of mRNAs in Drosophila development.
Authors:Jambor, Helena; Surendranath, Vineeth; Kalinka, Alex T.; Mejstrik, Pavel; Saalfeld, Stephan; Tomancak, Pavel
Date of Publication (YYYY-MM-DD):2015
Title of Journal:eLife
Volume:4
Sequence Number of Article:e05003
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:mRNA localization is critical for eukaryotic cells and affects numerous transcripts, yet how cells regulate distribution of many mRNAs to their subcellular destinations is still unknown. We combined transcriptomics and systematic imaging to determine the tissue-specific expression and subcellular distribution of 5862 mRNAs during Drosophila oogenesis. mRNA localization is widespread in the ovary and detectable in all of its cell types-the somatic epithelial, the nurse cells, and the oocyte. Genes defined by a common RNA localization share distinct gene features and differ in expression level, 3'UTR length and sequence conservation from unlocalized mRNAs. Comparison of mRNA localizations in different contexts revealed that localization of individual mRNAs changes over time in the oocyte and between ovarian and embryonic cell types. This genome scale image-based resource (Dresden Ovary Table, DOT.
External Publication Status:published
Document Type:Article
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6142
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