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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2015 (arch)     Display Documents



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ID: 717968.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2015 (arch)
The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle.
Authors:Spletter, Maria L; Barz, Christiane; Yeroslaviz, Assa; Schönbauer, Cornelia; Ferreira, Irene R S; Sarov, Mihail; Gerlach, Daniel; Stark, Alexander; Habermann, Bianca; Schnorrer, Frank
Date of Publication (YYYY-MM-DD):2015
Title of Journal:EMBO Reports
Volume:16
Issue / Number:2
Start Page:178
End Page:191
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:In Drosophila, fibrillar flight muscles (IFMs) enable flight, while tubular muscles mediate other body movements. Here, we use RNA-sequencing and isoform-specific reporters to show that spalt major (salm) determines fibrillar muscle physiology by regulating transcription and alternative splicing of a large set of sarcomeric proteins. We identify the RNA-binding protein Arrest (Aret, Bruno) as downstream of salm. Aret shuttles between the cytoplasm and nuclei and is essential for myofibril maturation and sarcomere growth of IFMs. Molecularly, Aret regulates IFM-specific splicing of various salm-dependent sarcomeric targets, including Stretchin and wupA (TnI), and thus maintains muscle fiber integrity. As Aret and its sarcomeric targets are evolutionarily conserved, similar principles may regulate mammalian muscle morphogenesis.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6095
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