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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2015 (arch)     Display Documents



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ID: 717984.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2015 (arch)
Quantitative profiling of endocannabinoids in lipoproteins by LC-MS/MS.
Authors:Bilgin, Mesut; Bindila, Laura; Graessler, Juergen; Shevchenko, Andrej
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Analytical and Bioanalytical Chemistry
Volume:407
Issue / Number:17
Start Page:5125
End Page:5131
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Endocannabinoids belong to a diverse family of endogenous lipid bioregulators acting as physiological ligands of cannabinoid receptor type 1 and cannabinoid receptor type 2 in the central and peripheral nervous system. They are also present in nmol L(-1) concentrations in human blood plasma; however, their association with possible molecular carriers remains poorly characterized. Here we report on the quantification of 46 endogenous molecular species from five major classes of endocannabinoids and endocannabinoid-related compounds in three lipoprotein fractions of human blood plasma: VLDL, LDL, HDL, and in the plasma lipoprotein-free fraction. Although sizable quantities of endocannabinoid-related molecules are associated with lipoproteins, we identified the lipoprotein-free fraction as a major carrier of endocannabinoids in blood circulation with the exception of 2-acylglycerols, which are markedly abundant in VLDL.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6178
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