Please note that eDoc will be permanently shut down in the first quarter of 2021!      Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2015 (arch)     Display Documents



ID: 717989.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2015 (arch)
A Spatial Model of Insulin-Granule Dynamics in Pancreatic β-Cells.
Authors:Dehghany, J; Hoboth, Peter; Ivanova, Anna; Mziaut, Hassan; Müller, Andreas; Kalaidzidis, Yannis; Solimena, Michele; Meyer-Hermann, M
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Traffic (Copenhagen, Denmark)
Volume:16
Issue / Number:8
Start Page:797
End Page:813
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Insulin secretion from pancreatic β-cells in response to sudden glucose stimulation is biphasic. Prolonged secretion in vivo requires synthesis, delivery to the plasma membrane (PM) and exocytosis of insulin secretory granules (SGs). Here, we provide the first agent-based space-resolved model for SG dynamics in pancreatic β-cells. Using recent experimental data, we consider a single β-cell with identical SGs moving on a phenomenologically represented cytoskeleton network. A single exocytotic machinery mediates SG exocytosis on the PM. This novel model reproduces the measured spatial organization of SGs and insulin secretion patterns under different stimulation protocols. It proposes that the insulin potentiation effect and the rising second-phase secretion are mainly due to the increasing number of docking sites on the PM. Furthermore, it shows that 6 min after glucose stimulation, the 'newcomer' SGs are recruited from a region within less than 600 nm from the PM.
External Publication Status:published
Document Type:Article
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6260
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.