Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2015 (arch)     Display Documents



  history
ID: 718015.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2015 (arch)
Mechanisms of Beta Cell Dysfunction Associated With Viral Infection.
Authors:Petzold, Antje; Solimena, Michele; Knoch, Klaus-Peter
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Current Diabetes Reports
Volume:15
Issue / Number:10
Sequence Number of Article:654
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Type 1 diabetes (T1D) results from genetic predisposition and environmental factors leading to the autoimmune destruction of pancreatic beta cells. Recently, a rapid increase in the incidence of childhood T1D has been observed worldwide; this is too fast to be explained by genetic factors alone, pointing to the spreading of environmental factors linked to the disease. Enteroviruses (EVs) are perhaps the most investigated environmental agents in relationship to the pathogenesis of T1D. While several studies point to the likelihood of such correlation, epidemiological evidence in its support is inconclusive or in some instances even against it. Hence, it is still unknown if and how EVs are involved in the development of T1D. Here we review recent findings concerning the biology of EV in beta cells and the potential implications of this knowledge for the understanding of beta cell dysfunction and autoimmune destruction in T1D.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6275
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.