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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2015 (arch)     Display Documents



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ID: 718024.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2015 (arch)
Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment.
Authors:Bowne-Anderson, Hugo; Hibbel, Anneke; Howard, Jonathon
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Trends in Cell Biology
Volume:25
Issue / Number:12
Start Page:769
End Page:779
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Recent studies have found that microtubule-associated proteins (MAPs) can regulate the dynamical properties of microtubules in unexpected ways. For most MAPs, there is an inverse relationship between their effects on the speed of growth and the frequency of catastrophe, the conversion of a growing microtubule to a shrinking one. Such a negative correlation is predicted by the standard GTP-cap model, which posits that catastrophe is due to loss of a stabilizing cap of GTP-tubulin at the end of a growing microtubule. However, many other MAPs, notably Kinesin-4 and combinations of EB1 with XMAP215, contradict this general rule. In this review, we show that a more nuanced, but still simple, GTP-cap model, can account for the diverse regulatory activities of MAPs.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6386
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