Please note that eDoc will be permanently shut down in the first quarter of 2021!      Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2015 (arch)     Display Documents



  history
ID: 718049.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2015 (arch)
Kinesin-8 motors improve nuclear centering by promoting microtubule catastrophe.
Authors:Glunčić, Matko; Maghelli, Nicola; Krull, Alexander; Krstić, Vladimir; Ramunno-Johnson, Damien; Pavin, Nenad; Tolić, Iva M
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Physical Review Letters
Volume:114
Issue / Number:7
Sequence Number of Article:078103
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:In fission yeast, microtubules push against the cell edge, thereby positioning the nucleus in the cell center. Kinesin-8 motors regulate microtubule catastrophe; however, their role in nuclear positioning is not known. Here we develop a physical model that describes how kinesin-8 motors affect nuclear centering by promoting a microtubule catastrophe. Our model predicts the improved centering of the nucleus in the presence of motors, which we confirmed experimentally in living cells. The model also predicts a characteristic time for the recentering of a displaced nucleus, which is supported by our experiments where we displaced the nucleus using optical tweezers.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:5986
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.