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| ID:
718054.0,
MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2015 (arch) |
| SAMHD1 prevents autoimmunity by maintaining genome stability. |
| Authors: | Kretschmer, Stefanie; Wolf, Christine; König, Nadja; Staroske, Wolfgang; Guck, Jochen; Häusler, Martin; Luksch, H; Nguyen, Laura A; Kim, Baek; Alexopoulou, Dimitra; Dahl, Andreas; Rapp, Alexander; Cardoso, M Cristina; Shevchenko, Anna; Lee-Kirsch, Min Ae | | Date of Publication (YYYY-MM-DD): | 2015 | | Title of Journal: | Annals of the Rheumatic Diseases | | Volume: | 74 | | Issue / Number: | 3 | | Sequence Number of Article: | e17 | | Copyright: | not available | | Audience: | Experts Only | | Intended Educational Use: | No | | Abstract / Description: | The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs). Mutations in SAMHD1 cause Aicardi-Goutières syndrome (AGS), an inflammatory disorder that shares phenotypic similarity with systemic lupus erythematosus, including activation of antiviral type 1 interferon (IFN). To further define the pathomechanisms underlying autoimmunity in AGS due to SAMHD1 mutations, we investigated the physiological properties of SAMHD1. | | External Publication Status: | published | | Document Type: | Article | | Version Comment: | Automatic journal name synchronization |
| Communicated by: | Thüm | | Affiliations: | MPI für molekulare Zellbiologie und Genetik
| | Identifiers: | LOCALID:6135 | |
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