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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2015 (arch)     Display Documents



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ID: 718054.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2015 (arch)
SAMHD1 prevents autoimmunity by maintaining genome stability.
Authors:Kretschmer, Stefanie; Wolf, Christine; König, Nadja; Staroske, Wolfgang; Guck, Jochen; Häusler, Martin; Luksch, H; Nguyen, Laura A; Kim, Baek; Alexopoulou, Dimitra; Dahl, Andreas; Rapp, Alexander; Cardoso, M Cristina; Shevchenko, Anna; Lee-Kirsch, Min Ae
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Annals of the Rheumatic Diseases
Volume:74
Issue / Number:3
Sequence Number of Article:e17
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs). Mutations in SAMHD1 cause Aicardi-Goutières syndrome (AGS), an inflammatory disorder that shares phenotypic similarity with systemic lupus erythematosus, including activation of antiviral type 1 interferon (IFN). To further define the pathomechanisms underlying autoimmunity in AGS due to SAMHD1 mutations, we investigated the physiological properties of SAMHD1.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Thüm
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:6135
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