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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook 2016     Display Documents



ID: 723914.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook 2016
Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension
Authors:Tiede, H.; Rorzyczka, J.; Dumitrascu, R.; Belly, M.; Reichenberger, F.; Ghofrani, H. A.; Seeger, W.; Heitmann, J.; Schulz, R.
Date of Publication (YYYY-MM-DD):2015
Title of Journal:BMC Pulm Med
Volume:15
Start Page:11
Audience:Not Specified
Abstract / Description:BACKGROUND: Patients with precapillary pulmonary hypertension (PH) have been reported to suffer from poor sleep quality, however, if this is related to physical exercise performance has not yet been thoroughly investigated. METHODS: Clinically stable out-patients with idiopathic pulmonary arterial hypertension (IPAH, n = 52) and chronic thromboembolic PH (CTEPH, n = 64) in NYHA classes II and III were prospectively enrolled. 54 healthy volunteers matched for anthropometric variables served as a control group. The Pittsburgh Sleep Quality Index (PSQI) was used to rate subjective sleep quality. In the PH patients, six-minute walk tests (6MWT) were performed to assess exercise capacity. RESULTS: Poor sleep quality (i.e. a PSQI score > 5) occurred more frequently in PH (IPAH: n = 25 [48.1%], CTEPH: n = 39 [60.9%], controls: n = 10 [18.5%]; p < 0.01 when compared to controls). In addition, poor vs. good sleepers had significantly higher average NYHA class (IPAH: 2.6 +/- 0.1 vs. 2.3 +/- 0.1, CTEPH: 2.8 +/- 0.1 vs. 2.3 +/- 0.2; p < 0.01) and shorter 6MWT distances (IPAH: 338 +/- 23 vs. 441 +/- 29 m, CTEPH: 355 +/- 15 vs. 413 +/- 26 m; p < 0.05). CONCLUSIONS: Self-reported poor sleep quality is more common in PH than in healthy controls. Furthermore, it is related to reduced physical exercise capacity.
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Department of Sleep Medicine, University of Giessen Lung Center, Klinikstr. 33, 35392, Giessen, Germany. janetrorzyczka@arcor.de. Department of Sleep Medicine, University of Giessen Lung Center, Klinikstr. 33, 35392, Giessen, Germany. Rio.Dumitrascu@innere.med.uni-giessen.de. Department of Sleep Medicine, University of Giessen Lung Center, Klinikstr. 33, 35392, Giessen, Germany. Michael.Belly@innere.med.uni-giessen.de. Department of Pneumology, Asklepios Lung Center, Munich-Gauting, Germany. f.reichenberger@asklepios.com. Department of Sleep Medicine, University of Giessen Lung Center, Klinikstr. 33, 35392, Giessen, Germany. h.ghofrani@kerckhoff-klinik.de. Department of Sleep Medicine, University of Giessen Lung Center, Klinikstr. 33, 35392, Giessen, Germany. Werner.Seeger@innere.med.uni-giessen.de. Department of Sleep Medicine, University of Giessen Lung Center, Klinikstr. 33, 35392, Giessen, Germany. heitmann_j@yahoo.de. Department of Sleep Medicine, University of Giessen Lung Center, Klinikstr. 33, 35392, Giessen, Germany. Richard.Schulz@innere.med.uni-giessen.de.
Identifiers:ISSN:1471-2466 (Electronic) 1471-2466 (Linking) %R 10.1186/s12890-015-0005-3
URL:http://www.ncbi.nlm.nih.gov/pubmed/25888026
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