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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook 2016     Display Documents



ID: 723922.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook 2016
Making sense of anti-sense data
Authors:Stainier, D. Y.; Kontarakis, Z.; Rossi, A.
Date of Publication (YYYY-MM-DD):2015-01-12
Title of Journal:Dev Cell
Volume:32
Issue / Number:1
Start Page:7
End Page:8
Audience:Not Specified
Abstract / Description:The morpholino anti-sense technology has been used extensively to test gene function. The zebrafish model allows a detailed comparison of knockdown (anti-sense) and knockout (mutation) effects. Recent studies reveal that these two approaches can often lead to surprisingly different phenotypes, thus raising a number of important questions.
Free Keywords:Animals; Gene Expression Regulation/*drug effects; Gene Knockdown Techniques/*methods; Morpholinos/*pharmacology; Oligonucleotides, Antisense/*pharmacology; Phenotype; Zebrafish/*genetics; Zebrafish Proteins/antagonists & inhibitors/*genetics
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.
Identifiers:ISSN:1878-1551 (Electronic) 1534-5807 (Linking) %R 10.1016/j.devcel.2014.12.012
URL:http://www.ncbi.nlm.nih.gov/pubmed/25584794
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