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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook 2016     Display Documents



ID: 723939.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook 2016
Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
Authors:Retailleau, K.; Duprat, F.; Arhatte, M.; Ranade, S. S.; Peyronnet, R.; Martins, J. R.; Jodar, M.; Moro, C.; Offermanns, S.; Feng, Y.; Demolombe, S.; Patel, A.; Honore, E.
Date of Publication (YYYY-MM-DD):2015-11-10
Title of Journal:Cell Rep
Volume:13
Issue / Number:6
Start Page:1161
End Page:1171
Audience:Not Specified
Abstract / Description:The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels. However, the role of stretch-activated ion channels (SACs) in arterial smooth muscle cells in the adult remains unknown. Here, we show that Piezo1 is highly expressed in myocytes of small-diameter arteries and that smooth-muscle-specific Piezo1 deletion fully impairs SAC activity. While Piezo1 is dispensable for the arterial myogenic tone, it is involved in the structural remodeling of small arteries. Increased Piezo1 opening has a trophic effect on resistance arteries, influencing both diameter and wall thickness in hypertension. Piezo1 mediates a rise in cytosolic calcium and stimulates activity of transglutaminases, cross-linking enzymes required for the remodeling of small arteries. In conclusion, we have established the connection between an early mechanosensitive process, involving Piezo1 in smooth muscle cells, and a clinically relevant arterial remodeling.
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Department of Molecular and Cellular Neuroscience, Howard Hughes Medical Institute, The Scripps Research Institute, La Jolla, CA 92037, USA. Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. Department of Neurology, Northwestern University, Chicago, IL 60611, USA. Institut de Pharmacologie Moleculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Universite de Nice Sophia Antipolis, 06560 Valbonne, France. Electronic address: patel@ipmc.cnrs.fr. Institut de Pharmacologie Moleculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Universite de Nice Sophia Antipolis, 06560 Valbonne, France. Electronic address: honore@ipmc.cnrs.fr.
Identifiers:ISSN:2211-1247 (Electronic) %R 10.1016/j.celrep.2015.09.072
URL:http://www.ncbi.nlm.nih.gov/pubmed/26526998
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