Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook 2016     Display Documents



ID: 723963.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook 2016
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
Authors:Macia, L.; Tan, J.; Vieira, A. T.; Leach, K.; Stanley, D.; Luong, S.; Maruya, M.; Ian McKenzie, C.; Hijikata, A.; Wong, C.; Binge, L.; Thorburn, A. N.; Chevalier, N.; Ang, C.; Marino, E.; Robert, R.; Offermanns, S.; Teixeira, M. M.; Moore, R. J.; Flavell, R. A.; Fagarasan, S.; Mackay, C. R.
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Nat Commun
Volume:6
Start Page:6734
Audience:Not Specified
Abstract / Description:Diet and the gut microbiota may underpin numerous human diseases. A major metabolic product of commensal bacteria are short-chain fatty acids (SCFAs) that derive from fermentation of dietary fibre. Here we show that diets deficient or low in fibre exacerbate colitis development, while very high intake of dietary fibre or the SCFA acetate protects against colitis. SCFAs binding to the 'metabolite-sensing' receptors GPR43 and GPR109A in non-haematopoietic cells mediate these protective effects. The inflammasome pathway has hitherto been reported as a principal pathway promoting gut epithelial integrity. SCFAs binding to GPR43 on colonic epithelial cells stimulates K(+) efflux and hyperpolarization, which lead to NLRP3 inflammasome activation. Dietary fibre also shapes gut bacterial ecology, resulting in bacterial species that are more effective for inflammasome activation. SCFAs and metabolite receptors thus explain health benefits of dietary fibre, and how metabolite signals feed through to a major pathway for gut homeostasis.
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:1] Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia [2] Department of Biochemistry and Immunology, Immunopharmacology Group, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. 1] CSIRO Animal, Food and Health Sciences, Australian Animal Health Laboratories, Private Bag 24, Geelong, Victoria 3220, Australia [2] Central Queensland University, School of Medical and Applied Sciences, Bruce Highway, Rockhampton, Queensland 4702, Australia. Laboratory for Mucosal Immunity, 6 Laboratory for Immunogenomics, RIKEN Research Center for Allergy and Immunology Tsurumi, Yokohama 230-0045, Japan. Max-Planck-Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany. Department of Biochemistry and Immunology, Immunopharmacology Group, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. 1] CSIRO Animal, Food and Health Sciences, Australian Animal Health Laboratories, Private Bag 24, Geelong, Victoria 3220, Australia [2] ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria 3800, Australia. 1] Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA [2] Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Identifiers:ISSN:2041-1723 (Electronic) 2041-1723 (Linking) %R 10.1038/ncomms7734
URL:http://www.ncbi.nlm.nih.gov/pubmed/25828455
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.