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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook 2016     Display Documents



ID: 723985.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook 2016
Animal Models and "Omics" Technologies for Identification of Novel Biomarkers and Drug Targets to Prevent Heart Failure
Authors:Hou, Y.; Adrian-Segarra, J. M.; Richter, M.; Kubin, N.; Shin, J.; Werner, I.; Walther, T.; Schonburg, M.; Poling, J.; Warnecke, H.; Braun, T.; Kostin, S.; Kubin, T.
Date of Publication (YYYY-MM-DD):2015
Title of Journal:Biomed Res Int
Volume:2015
Start Page:212910
Audience:Not Specified
Abstract / Description:It is now accepted that heart failure (HF) is a complex multifunctional disease rather than simply a hemodynamic dysfunction. Despite its complexity, stressed cardiomyocytes often follow conserved patterns of structural remodelling in order to adapt, survive, and regenerate. When cardiac adaptations cannot cope with mechanical, ischemic, and metabolic loads efficiently or become chronically activated, as, for example, after infection, then the ongoing structural remodelling and dedifferentiation often lead to compromised pump function and patient death. It is, therefore, of major importance to understand key events in the progression from a compensatory left ventricular (LV) systolic dysfunction to a decompensatory LV systolic dysfunction and HF. To achieve this, various animal models in combination with an "omics" toolbox can be used. These approaches will ultimately lead to the identification of an arsenal of biomarkers and therapeutic targets which have the potential to shape the medicine of the future.
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Department of Cardiac Surgery, Kerckhoff Clinic, Benekestrasse 2-8, 61231 Bad Nauheim, Germany. Department of Thoracic and Cardiac Surgery, Goethe University Frankfurt am Main, 60323 Frankfurt am Main, Germany. Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany ; Department of Cardiac Surgery, Schuchtermann-Clinic, Ulmenallee 11, 49214 Bad Rothenfelde, Germany. Department of Cardiac Surgery, Schuchtermann-Clinic, Ulmenallee 11, 49214 Bad Rothenfelde, Germany ; University of Witten/Herdecke, Alfred-Herrhausen-Strasse 50, 58448 Witten, Germany.
Identifiers:ISSN:2314-6141 (Electronic) %R 10.1155/2015/212910
URL:http://www.ncbi.nlm.nih.gov/pubmed/26236717
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