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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Yearbook 2016     Display Documents



ID: 724006.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Yearbook 2016
Ovarian carcinoma-infiltrating regulatory T cells were more potent suppressors of CD8 T cell inflammation than their peripheral counterparts, a function dependent on TIM3 expression
Authors:Bu, M.; Shen, Y.; Seeger, W. L.; An, S.; Qi, R.; Sanderson, J. A.; Cai, Y.
Date of Publication (YYYY-MM-DD):2015-10-19
Title of Journal:Tumour Biol
Audience:Not Specified
Abstract / Description:Ovarian carcinoma is one of the most severe cancers in women, with a high relapse rate and limited secondary treatment options. To assist research in novel treatment technologies, including CD8+ T cell-base immunotherapy, we examined the effect of tumor-infiltrating regulatory T cells (Tregs) in inhibiting CD8+ T cell inflammation. We found that compared to their peripheral blood counterparts, tumor-infiltrating Tregs exhibited more potent inhibitory function, which was associated with higher interleukin 10 (IL-10) production in tumor-infiltrating Tregs. Blockade of T cell immunoglobulin mucin 3 (TIM3), a regulatory molecule overrepresented on tumor-infiltrating Tregs, had significantly reverted Treg-mediated suppression. Moreover, expression of TIM3 on tumor-infiltrating Tregs was directly correlated with tumor size. Together, our results demonstrated that ovarian tumor-infiltrating Treg cells were more immunosuppressive than their peripheral blood counterparts in a TIM3-dependent fashion.
Free Keywords:Ovarian cancer; Regulatory T cell; Tim3; Tumor-infiltrating lymphocyte
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Department of Urology, General Hospital of Jinan Military Command, Jinan, Shandong, 250031, China. Research Center, Lingbin Biotechnology, Surrey, BC, Canada. Department of Prenatal Diagnosis, The Maternal and Child Health Hospital of Jinan City, No.2 Jian Guo Xiao Jing San Road, Jinan, Shandong, 250001, China. yancai_jn@sina.com.
Identifiers:ISSN:1423-0380 (Electronic) 1010-4283 (Linking) %R 10.1007/s13277-015-4237-x
URL:http://www.ncbi.nlm.nih.gov/pubmed/26482613
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