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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2017 (publ. 2016, arch)     Display Documents



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ID: 732117.0, MPI für molekulare Biomedizin / Jahrbuch 2017 (publ. 2016, arch)
Go ahead, grow a head! A planarian's guide to anterior regeneration
Authors:Owlarn, S.; Bartscherer, K.
Date of Publication (YYYY-MM-DD):2016-06
Title of Journal:Regeneration (Oxf)
Volume:3
Issue / Number:3
Start Page:139
End Page:155
Review Status:Internal review
Audience:Not Specified
Abstract / Description:The unique ability of some planarian species to regenerate a head de novo, including a functional brain, provides an experimentally accessible system in which to study the mechanisms underlying regeneration. Here, we summarize the current knowledge on the key steps of planarian head regeneration (head-versus-tail decision, anterior pole formation and head patterning) and their molecular and cellular basis. Moreover, instructive properties of the anterior pole as a putative organizer and in coordinating anterior midline formation are discussed. Finally, we highlight that regeneration initiation occurs in a two-step manner and hypothesize that wound-induced and existing positional cues interact to detect tissue loss and together determine the appropriate regenerative outcomes.
Free Keywords:Organizer; Wnt; patterning; planaria; polarity; regeneration; wound
External Publication Status:published
Document Type:Article
Communicated by:Jeanine Müller-Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Max Planck Research Group Stem Cells and RegenerationMax Planck Institute for Molecular BiomedicineVon-Esmarch-Str. 5448149MunsterGermany; Medical FacultyUniversity of MunsterAlbert-Schweitzer-Campus 148149MunsterGermany.
Identifiers:ISSN:2052-4412 (Linking) %R 10.1002/reg2.56 [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/27606065 [ID No:2]
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