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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2017 (publ. 2016, arch)     Display Documents

ID: 732121.0, MPI für molekulare Biomedizin / Jahrbuch 2017 (publ. 2016, arch)
Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling
Authors:Mondor, I.; Jorquera, A.; Sene, C.; Adriouch, S.; Adams, R. H.; Zhou, B.; Wienert, S.; Klauschen, F.; Bajenoff, M.
Date of Publication (YYYY-MM-DD):2016-10
Title of Journal:Immunity
Issue / Number:4
Start Page:877
End Page:888
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Lymph node (LN) expansion during an immune response relies on the transient remodeling of its vasculature. Although the mechanisms driving LN endothelial cell division are beginning to be understood, a comprehensive view of LN endothelial cell dynamics at the single-cell level is lacking. Here, we used multicolored fluorescent fate-mapping models to track the behavior of blood endothelial cells during LN expansion upon inflammation and subsequent return to homeostasis. We found that expansion of the LN vasculature relied on the sequential assembly of endothelial cell proliferative units. This segmented growth was sustained by the clonal proliferation of high endothelial venule (HEV) cells, which act as local progenitors to create capillaries andHEVneo-vessels at the periphery of the LN. Return to homeostasis was accompanied by the stochastic death of pre-existing and neo-synthesized LN endothelial cells. Thus, our fate-mapping studies unravel-at a single-cell level-the complex dynamics of vascular-tree remodeling during LN expansion and contraction.
Free Keywords:high endothelial venules; follicular dendritic cells; mouse-brain; tip; cells; angiogenesis; tissue; homeostasis; mechanisms; expression; growth; Immunology
External Publication Status:published
Document Type:Article
Communicated by:Jeanine Müller-Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Bajenoff, M (reprint author), Aix Marseille Univ, CNRS, INSERM, CIML, F-13288 Marseille, France. %G English
Identifiers:ISSN:1074-7613 %R 10.1016/j.immuni.2016.09.017 [ID No:1]
URL:<Go to ISI>://WOS:000389473200018 [ID No:2]
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