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          Institute: MPI für molekulare Biomedizin     Collection: Jahrbuch 2017 (publ. 2016, arch)     Display Documents



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ID: 732147.0, MPI für molekulare Biomedizin / Jahrbuch 2017 (publ. 2016, arch)
Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells
Authors:Grainger, S.; Richter, J.; Palazon, R. E.; Pouget, C.; Lonquich, B.; Wirth, S.; Grassme, K. S.; Herzog, W.; Swift, M. R.; Weinstein, B. M.; Traver, D.; Willert, K.
Date of Publication (YYYY-MM-DD):2016-11-01
Title of Journal:Cell Rep
Volume:17
Issue / Number:6
Start Page:1595
End Page:1606
Review Status:Internal review
Audience:Not Specified
Abstract / Description:All mature blood cell types in the adult animal arise from hematopoietic stem and progenitor cells (HSPCs). However, the developmental cues regulating HSPC ontogeny are incompletely understood. In particular, the details surrounding a requirement for Wnt/beta-catenin signaling in the development of mature HSPCs are controversial and difficult to consolidate. Using zebrafish, we demonstrate that Wnt signaling is required to direct an amplification of HSPCs in the aorta. Wnt9a is specifically required for this process and cannot be replaced by Wnt9b or Wnt3a. This proliferative event occurs independently of initial HSPC fate specification, and the Wnt9a input is required prior to aorta formation. HSPC arterial amplification occurs prior to seeding of secondary hematopoietic tissues and proceeds, in part, through the cell cycle regulator myca (c-myc). Our results support a general paradigm, in which early signaling events, including Wnt, direct later HSPC developmental processes.
Free Keywords:HSCs; HSPCs; Myc; Wnt; Wnt9a; aorta; hematopoietic stem and progenitor cells; hematopoietic stem cells; proliferation
External Publication Status:published
Document Type:Article
Communicated by:Jeanine Müller-Keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Biomedical Sciences Graduate Studies, University of California, San Diego, La Jolla, CA 92037, USA. University of Munster, 48149 Munster, Germany. University of Munster, 48149 Munster, Germany; Max-Planck-Institute for Molecular Biomedicine, Munster, Germany; Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Munster, 48149 Munster, Germany. Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. Section on Vertebrate Organogenesis, Division of Developmental Biology, NICHD, NIH, Bethesda, MD 20892, USA. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: dtraver@ucsd.edu. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: kwillert@ucsd.edu.
Identifiers:ISSN:2211-1247 (Electronic) %R 10.1016/j.celrep.2016.10... [ID No:1]
URL:https://www.ncbi.nlm.nih.gov/pubmed/27806298 [ID No:2]
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